Conditional Knockout of Brain-Derived Neurotrophic Factor in the Hippocampus Increases Death of Adult-Born Immature Neurons following Traumatic Brain Injury

Authors

Xiang Gao, Jinhui Chen

Abstract

It has been reported that the hippocampus is particularly vulnerable to traumatic brain injury (TBI), the consequence of which results in hippocampal-dependent cognitive impairment. In the previous study we found that adult-born immature neurons in the hippocampal dentate gyrus are the most vulnerable cell type to moderate TBI insult. However, the molecular mechanisms that regulate the survival of adult-born immature neurons in the hippocampus following TBI are still not well understood. Here, we conditionally knocked out brain-derived neurotrophic factor (BDNF) in the hippocampal dentate gyrus and examined the death of adult-born immature neurons following moderate TBI. The results showed that the amount of adult-born immature neuron death in the hippocampal dentate gyrus significantly increased in the BDNF conditional knockout mice. This result suggests that BDNF is involved in regulating the survival of adult-born immature neurons in the hippocampus following TBI, and potentially might be a useful target for preventing the adult-born immature neurons from death following TBI.